Developmental Programming in Animal Models: Critical Evidence of Current Environmental Negative ChangesReview Published on 2023-02-012023-07-09 Journal: Reproductive Sciences [Category] COVID19(2023년), [키워드] animal models gestation lactation Maternal programming metabolism New epigenetic factors. [DOI] 10.1007/s43032-022-00999-8 PMC 바로가기 [Article Type] Review
Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory MiceArticle Published on 2022-12-302023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] animal models Brain COVID-19 Mouse-adaptation Neuroinflammation. SARS-CoV-2 [DOI] 10.3390/v15010114 PMC 바로가기
3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Safety and immunogenicity of the first Kazakh inactivated vaccine for COVID-19Article Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] SARS, 진단, [키워드] adverse effect animal models antibody Antibody titer BALB/c mice changes in class COVID-19 COVID-19 vaccine demonstrated did not produce ELISA ENhance enzyme-linked immunosorbent ferrets Gender general condition GMT group growth hamster hamsters Health histology immune response immunization immunogenicity Inactivated vaccine injection internal organ Kazakhstan lowest microneutralization MNA nontoxic preclinical trials rhesus macaque Safety significant difference statistically significant Toxicity Vaccine vaccine. were assessed [DOI] 10.1080/21645515.2022.2087412 PMC 바로가기
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing VirusArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome animal models antiviral therapeutics antivirals biology of SARS-CoV-2 Care caused comparable contagious coronavirus coronavirus disease COVID-19 cultured cells demonstrated detect Express expresse expressing expression level facilitate feasibility fluorescent Genes hACE2 hamster Health human Angiotensin-converting enzyme in vitro In vitro assay in vivo infected cell Infection K18 knowledge limitation luciferase luciferase reporter gene luciferase reporter genes mCherry monitoring neutralizing antibody overcome pandemic pathogenicity Protein recombinant reporter responsible robust SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection transgenic mice Transmission Transmission. Vaccine viral fitness viral infection virus wild-type [DOI] 10.1128/spectrum.02379-22 PMC 바로가기
Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular MechanismsArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] 신약개발, 진단, [키워드] accompanied activity addition aging all-cause mortality animal model animal models available data benefit Biomarker blunt caloric restriction calories cardiovascular diseases Cardiovascular outcomes cellular senescence clinical study clinical trials Compound COVID-19 decrease diabetes driver drug drugs employment Evidence Fatty acid feature Glucose heart failure humans IL-6 independent inflammaging Inflammasome inhibitor inhibitors intrinsic Kidney disease low-grade inflammation meta-analysis modulating modulation molecular Mortality nutrient-sensing pathways observational studies outcomes pathway Patient promote provided repurposing selected senescence sodium-glucose cotransporter 2 inhibitors. substrates suggested Support systemic effects systemic level target Urine [DOI] 10.3390/ijms232012325 PMC 바로가기
Development and characterization of anti-SARS-CoV-2 intravenous immunoglobulin from COVID-19 convalescent plasmaArticle Published on 2022-10-012022-11-15 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 진단, [키워드] administration Adults allergenic animal models anti-SARS-CoV-2 clinical trial Concentration convalescent plasma COVID-19 COVID-globulin development developmental Efficacy hamster healthy hyperimmune hyperimmune immunoglobulin IgG Immunoglobulin immunoglobulin against COVID-19 Immunosuppressed inactivation intravenous Intravenous immunoglobulin investigated material Neutralizing plasma preclinical evaluation produced Protective protective efficacy. Protein purification Safe Safety SARS-CoV-2 SARS-CoV-2 neutralizing antibody Toxicity virus [DOI] 10.2217/imt-2022-0015 PMC 바로가기
Characteristics of animal models for COVID-19Article Published on 2022-10-012022-11-16 Journal: Animal models and experimental medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome animal model animal models applied blueprint Characteristics coronavirus coronavirus disease COVID-19 develop disease establishment. Genome group hamsters Health Infection Infection route manifestation MERS-CoV mice Mutation pandemic Pandemics pathogen resource SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic transmission route unique variants of concern World Health Organization [DOI] 10.1002/ame2.12278 PMC 바로가기
A self-assembled trimeric protein vaccine induces protective immunity against Omicron variantArticle Published on 2022-09-172022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] addition animal models B.1.1.529 Breakthrough infection circulating clinical trials Complete Delta delta variant dose elicited humoral immune response Immune escape immune response in vivo induce L452R Live virus mice mRNA vaccines neutralizing antibody non-human primates omicron predominant prime-boost regimen protective immunity Protein RBD resulting SARS-CoV-2 SARS-CoV-2 S2 SARS-CoV-2 vaccine SARS-CoV-2 variant sequence subunit surpassed sustained T cell T478K Transmissibility trimer trimeric vaccinated individuals vaccination Vaccine vaccine candidate variant variants [DOI] 10.1038/s41467-022-33209-9 PMC 바로가기
Engineering the common cold to be a live-attenuated SARS-CoV-2 vaccineArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] all age group animal models Antigen approach Asymptomatic Attenuated benefit catch caused center Characteristics common cold Control did not reduce drug effective effort Engineering Express healthy Hospitalization hosts Human Human rhinovirus immune response Immunity induce Infection intranasal intranasal vaccination live vaccine Mortality mucosal nasal swab pandemic coronavirus pathogen pathogenic prevention Protective Proteins reducing Replication replication competent respiratory virus rhinovirus rhinovirus Rhinovirus. rhinoviruses robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV2 serotype serum Social distancing measure Spread strain tested Vaccine vaccine candidate vector virus [DOI] 10.3389/fimmu.2022.871463 PMC 바로가기